ESPGHAN Summer School in Basics and Translational Research

Application Deadline: 28.05.2018

Registration Fee

Registration Fee (50.00€)

ESPGHAN summer school for Basic and Translational Research

Date: 25th to 27th July 2018   

Venue: Trinity Hall College, Cambridge, UK  

Target audience:    

• Clinicians and scientists involved in research related to ESPGHAN  

• Trainees as well as established researchers/clinicians are invited  

• Non-members require supporting statement from an active ESPGHAN member 

• ESPGHAN members who are interested in perusing basic and or translational research in the fields of paediatric gastroenterology, hepatology and nutrition  

This summer school aims to provide an introduction to basic and translational research methodologies specifically tailored to young clinical trainees, research students, post-docs as well as more established investigators working in the field of paediatric gastroenterology, hepatology and nutrition. Moreover, we aim to provide a platform for motivated individuals to meet, connect and receive guidance from an experienced international faculty.  

Talks and teaching sessions will cover the following topics:  

• Introduction in basic molecular research techniques (e.g. RT-PCR, Western blotting, ELISA, Immunostaining etc.)  

• Genome wide genetic, epigenetic and transcriptomic profiling  

  o Next generation sequencing and array based approaches  

• Introduction in bioinformatic analysis of the above datasets (using ‘R’) 

• Human intestinal organoids (or “how to grow a human mini-gut”) – novel translational research tools for Paediatric Gastroenterologists 

• Cutting edge research: CRISPR/Cas9 genome editing  

• Translational basic research (from bench to bedside) – how to make it happen  

• How to get published  

• Applying for funding (fellowships, grants)  

• How to combine clinical work and science / how to be research active  

• Discussion and critical appraisal of selected delegate projects   

The social programme will include a dinner at the historical College Dining Hall and punting on the river Cams. There will be plenty of opportunity for delegates to mingle with faculty members as well as amongst each other encouraging active exchange of ideas and start of possible collaborations.   

We will request applications, which will have to include the following :

1) CV  

2) Brief motivational statement  

3) Support letter from an ESPGHAN member (if application from non-member trainees) 

4) Abstract of either current or planned research project (basic and/or translational research) – top abstracts will be selected for presentation and discussion 

Max. Number of Delegates: 25  

The ESPGHAN Summer School in Basics and Translational Research, Cambridge, United Kingdom, 25/07/2018-27/07/2018 has been granted 8 European CME credits (ECMEC®s) by the European Accreditation Council for Continuing Medical Education (EACCME®).

ESPGHAN Summer School for Basic and Translational Research 

Cambridge: 25th to 27th July 2018  

Wednesday 25th July  


• Arrival of faculty and delegates  

• 18:00h Welcome networking event at Trinity Hall College followed by punting on the River Cams


Thursday 26th July  


Morning Session 


8:30 – 9:00 Registration and Coffee 

9:00  Welcome (M. Zilbauer) 

9:00 – 9:20 Basic and translational research – how to get started (M. Zilbauer) 

9:20 – 9:55 Epigenetics – basic principles and methodological approaches (A. Jenke and J. Postberg) 

9:55 – 10:25 MicroRNAs and their role as clinical biomarkers. Current knowledge and future challenges (L. Amar) 

10:15 – 10:45 Coffee break 

10:45 – 11:15 Human intestinal organoids  - translational research tools (J. Kraiczy) 

11:15 – 11:35 Genome wide profiling – an Introduction to methods and bioinformatic analyses (M. Gasparetto) 

11:35 – 12:00 Single Cell RNA sequencing (A. Ross) 

12:00 – 12:30 Questions – Discussions (All faculty) 

12:30 – 13:30 Lunch 

13:30 – 14:00 Publishing translational research – tips and considerations (K. Hensel) 

14:30 – 14:30 Balancing clinical work with research activities/training -  experiences from faculty members and delegate Q&A (A. Ross, M. Gasparetto, J. Mann, M. Zilbauer, R. Heuschkel, A. Jenke, K. Hensel) 


Afternoon break out session 


Delegates will be divided in 5 groups  


14:30 – 15:30 Meet the faculty - Discussion groups 20 minutes each  

Description: This is aimed at giving delegates the opportunity to meet with faculty and have a more detailed discussion about various aspects of related research and/or other topics. 


1) Large data analyses and bioinformatics  

- Alex Ross 

- Marco Gasparetto  

- Felicity Payne  


2) Basic research methodologies/organoids/CRISPR  

- Judith Kraiczy  

- Laurence Amar  

- Jan Postberg  


3) Clinical trials/clinical research/funding/training 

- Rob Heuschkel  

- Jake Mann 

- Matt Zilbauer  

- Kai Hensel 


15:30 – 17:30 Review of delegate abstracts and preparation for Dragon’s Den  

Description: Each group will be given 5-6 delegate abstracts (NOT their own). These will be scored and constructive feedback documented by the supervising faculty members.  

As a second task, the group will be asked to choose one abstract/project to be prepared for presentation in the ‘Science Dragon Den’. Briefly, in the Dragon’s Den, the group will have to convince dragons to fund their research project. They will be given 10-15 minutes presentation time followed by questions from the dragons. The group are allowed to modify the abstract (e.g. change methodologies, patient cohort etc) if they feel that this improves the quality of the project.  

The aim is to critically assess research projects and prepare for funding and/or publication. The Dragon’s den session will be held on Friday.  


Evening: Dinner in historical College Dining Hall  


Friday 27th July  


8:30 – 9:00 Coffee  

9:00 – 9:30 Clinical trials and collaborating with industry (R. Heuschkel) 

9:30 – 10:00 Setting up a clinical registry (J. Mann) 

10:00 – 10:15 Coffee break 

10:15 – 12:30 Science – Dragon’s Den (Delegates and all Faculty) 

12:30 - 12:45 Feedback from delegates 

12:45 Concluding remarks and summary (M. Zilbauer)

13:15 Lunch and departure 

Course director: 

Dr. Matthias Zilbauer MD PhD 


Local organisers:  

Dr. Robert Heuschkel 

Mrs Frances Goodfellow 





Prof. Andreas Jenke (Germany) 

Dr. Laurence Amar (France) 

Dr. Jan Postberg (Germany) 


Cambridge based:    

Dr. Judith Kraiczy PhD (Post-doctoral scientist)  

Dr. Marco Gasparetto, MD (Senior clinical fellow and MD student) 

Dr. Robert Heuschkel, MD (Consultant Paediatric Gastroenterologist)  

Dr. Alexander Ross (Academic Clinical Fellow and PhD student) 

Dr. Jake Mann (Academic Clinical Fellow and PhD student) 

Dr. Kai Hensel (Senior Clinical Fellow and Clinician scientist) 

Felicity Payne (Bioinformatician)