ESPGHAN Summer School in Basics and Translational Research

Application Deadline: 28.05.2018

Registration Fee

Registration Fee (50.00€)

ESPGHAN summer school for Basic and Translational Research

Date: 25th to 27th July 2018   

Venue: Trinity Hall College, Cambridge, UK  

Target audience:    

• Clinicians and scientists involved in research related to ESPGHAN  

• Trainees as well as established researchers/clinicians are invited  

• Non-members require supporting statement from an active ESPGHAN member 

• ESPGHAN members who are interested in perusing basic and or translational research in the fields of paediatric gastroenterology, hepatology and nutrition  

This summer school aims to provide an introduction to basic and translational research methodologies specifically tailored to young clinical trainees, research students, post-docs as well as more established investigators working in the field of paediatric gastroenterology, hepatology and nutrition. Moreover, we aim to provide a platform for motivated individuals to meet, connect and receive guidance from an experienced international faculty.  

Talks and teaching sessions will cover the following topics:  

• Introduction in basic molecular research techniques (e.g. RT-PCR, Western blotting, ELISA, Immunostaining etc.)  

• Genome wide genetic, epigenetic and transcriptomic profiling  

  o Next generation sequencing and array based approaches  

• Introduction in bioinformatic analysis of the above datasets (using ‘R’) 

• Human intestinal organoids (or “how to grow a human mini-gut”) – novel translational research tools for Paediatric Gastroenterologists 

• Cutting edge research: CRISPR/Cas9 genome editing  

• Translational basic research (from bench to bedside) – how to make it happen  

• How to get published  

• Applying for funding (fellowships, grants)  

• How to combine clinical work and science / how to be research active  

• Discussion and critical appraisal of selected delegate projects   

The social programme will include a dinner at the historical College Dining Hall and punting on the river Cams. There will be plenty of opportunity for delegates to mingle with faculty members as well as amongst each other encouraging active exchange of ideas and start of possible collaborations.   

We will request applications, which will have to include the following :

1) CV  

2) Brief motivational statement  

3) Support letter from an ESPGHAN member (if application from non-member trainees) 

4) Abstract of either current or planned research project (basic and/or translational research) – top abstracts will be selected for presentation and discussion 

Max. Number of Delegates: 25  

ESPGHAN Summer School for Basic and Translational Research 

Cambridge: 25th to 27th July 2018  

Wednesday 25th July

• Arrival of faculty and delegates  

• 18:00h Welcoming reception at Trinity Hall College followed by networking event

Thursday 26th July

Morning Session 

8:30 – 9:00h : Registration and Coffee 

9:00h: Welcome (M. Zilbauer) 

9:00 – 9:45h: Lab basics: from real-time PCR to western blotting (Cambridge Faculty) 

9:45 – 10:30h: Epigenetics – basic principles and methodological approaches (A. Jenke) 

10:30 – 10:45h: Coffee break 

10:45 – 11:30h: Genome wide molecular and genetic profiling – an Introduction (A. Ross and Cambridge Bioinformatician) 

11:30 – 12:15h: Human intestinal organoids  - translational research tools for Paediatric Gastroenterologists (including CRISPR/Cas9 genome editing) (M. Zilbauer, J. Kraiczy) 

12:15 – 13:30h: Lunch  

Afternoon Session   

Delegates will be divided in 3 groups, which will rotate through 3 stations (45min each – finishing 17:00h) followed by summary:      

1) Basic principles in biomedical research   

• How to set up an experiment, clinical trial, research study   

• What are the critical aspects in performing basic and translational research  

• The critical importance of choosing the appropriate control  

• What are confounders and how can we adjust for them  

• Ethical approval    

2) How to be successful in biomedical research/science 

• How to apply for funding  

• Career planning  

• Mentorship 

• Where to publish

• Impact factor: what does this mean, why does it matter where I publish my data 

• How to combine research with clinical training/practice   

3) How to critically assess a paper – and learn from it 

• brief presentation of scientific and/or clinical papers by faculty members 

• delegates will be asked to assess, comment  

• PDFs of selected papers will be circulated prior to meeting for delegates to read through  

• Selected Papers will include clinically related basic science articles, published in top journals (e.g. Science, Nature Medicine, Gastroenterology etc.) providing a sufficient challenge for delegates     

Thursday evening:

Dinner in historical College Dining Hall 

Friday 27th July

8:30 – 9:00h: Coffee 

9:00 – 10:00h: Clinical trials – all you need to know (R. Heuschkel, J. Mann) 

10:00 – 10:15h: Coffee break 

10:15 – 13:00h: Presentation of selected abstracts/research projects (focus will be on discussion and critical appraisal of study design – NOT results!!) (Delegates and Faculty) 

13:00h: Concluding remarks and summary (M. Zilbauer) 

13:15h: Lunch and departure  

Course director:

Dr. Matthias Zilbauer MD PhD

Cambridge based:  

Dr. Judith Kraiczy PhD

Dr. Marco Gasparetto, MD

Dr. Robert Heuschkel, MD

Dr. Alexander Ross (Academic Clinical Fellow and PhD student)

Dr. Jake Mann (Academic Clinical Fellow and PhD student)



Prof. Andreas Jenke (Oberhausen, Germany)

Prof. Jan Postberg PhD (Witten/Herdecke University, Germany)

Dr. Laurence Amar PhD (Paris, France)