ESPGHAN Monothematic Conference on The Gastrointestinal, Hepatologic and Nutritional Aspects of Cystic Fibrosis

Application Deadline: 17.02.2019



Registration Fee

Registration Fee (100.00€)


Exciting and significant new developments and advantages in the diagnosis, treatment and patient prognosis of cystic fibrosis (CF) have been achieved in recent years. However, CF remains a highly prevalent, multi-organ and severe life-limiting genetic disorder with important gastrointestinal, hepatologic and nutritional implication in children. And with the improved treatment of the pulmonary complications of cystic fibrosis (CF), gastrointestinal nutritional problems have become more important in the morbidity of CF patients. 

 

The CF phenotype results from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. As a result, the CF patients have, besides progressive lung disease several gastrointestinal, hepatologic and nutritional complications leading to a negative impact on disease evolution and life expectancy. 

 

In recent years there has been a huge and significant progress in the knowledge of the disease regarding genetics, pathogenesis, medical and nutritional management, new treatments, personalized medicine and patient self-management.  

 

The aim of this Monothematic Conference on CF is, by using classical as modern interactive educational tools, to give a comprehensive overview on the current status and new development  regarding the disease, in particular its gastrointestinal, hepatologic and nutritional  implication to provide a broad practical and scientific insight into recent findings in the field. 

 


Thursday 4 April   

 

Coordinators: Carmen Ribes-Koninckx, Frank Bodewes and Michael Wilschanski 

 

13:00-14:15 Arrival, registration and lunch 

14:15 Welcome (Carmen Ribes-Koninckx) 

 

14:30 – 16:00 SESSION 1: GENERAL ASPECTS Update 

Chair: Carmen Ribes-Koninckx, Frank Bodewes 

14:30 CFTR update 2019: A special focus on GI pathology (Michael Wilschanski) 

15:00 CFTR mutations: impact on pancreatic function (Isabelle Scheers)   

15:30 New Born Screening:  GI and Nutritional aspects. Consequences for early CFTR modulation treatments (Anne Munck)  

16:00 Coffee Break 

 

16:15 – 18:15 SESSION 2: A CLINICAL VIEW 

Chairs: Michael Wilschanski, Kris De Boeck 

16:15 CF Liver disease: from diagnosis to liver transplantation (Dominique Debray) 

16:45 Intestinal lipid absorption and bile salt regulation (Frank Bodewes) 

17:15 Dysmotility disorders in CF: much more than GERD (Etna Masip) 

17:45 Abdominal pain, differential diagnosis and management (Carla Colombo)  

 

Friday 5 April   

 

8:30- 9:30 SESSION 3: CLINICAL CASES 

Chairs:  Isabelle Scheers, Dominique Debray 

Clinical cases presented by the delegates 

Selected abstracts (total 6)  

 

9:30 – 12:00 SESSION 4: NUTRITIONAL ASPECTS 

Chairs: Anne Munck, Carla Colombo 

9:30 How to assess nutritional status? Anthropometry and biomarkers (Chris Smith) 

10:00 How to deal with malnutrition? (Jessie Hulst) 

10:30 Coffee Break 

11:00 Bone disease in cystic fibrosis: new pathogenic insights and novel therapies (Isabelle Sermet)  

11:30 CF-related glucose metabolism and impact on nutrition (Dimitri Declercq) 

12:00 Nutritional recommendations: Diet and PERT (Inês Asseiceira)  

12:30 Lunch 

 

13:30 SESSION 5: NEW THERAPIES AND STRATEGIES 

Chairs: Michael Wilschanski, Jessie Hulst 

13:30 New evidences and opportunities on PERT. MyCyFAPP H2020  

13:30-13-40 MyCyFAPP: Innovative approach for nutrition and PERT self-management in CF (Carmen Ribes) 

13:40-14:00 New evidence-based method to adjust PERT (Joaquim Calvo Lerma) 

14:00-14:15 Lessons learnt from MyCyFAPP clinical trial (Paula Crespo Escobar) 

14:15 Pancreas transplantation, does it have a place in CF treatment? (Frank Bodewes) 

14:45 Do CFTR modulator therapies improve GI outcomes? (Kris De Boeck) 

15:00 Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis and to evaluate new therapies outcomes (Karin de Winter) 

15:30 End of the course & Farewell 




Local organisers:  Carmen Ribes Koninckx (Spain), Frank Bodewes (the Netherlands), Michael Wilschanski (Israel) 


Faculty: 

Jessie Hulst 

Chris Smith 

Ines Asseiceria 

Dimitri Declerq 

Dominique Debray 

Anne Munck 

Carla Colombo 

Kris De Boeck 

Isabelle Scheers 

Etna Masip 

Paula Crespo 

Joaquim Calvo 

Karin de Winter 

Isabelle Sermet