Knowledge in the diagnostic and therapeutic management of several liver diseases of has increased in the past decades. However, management of acute liver failure (ALF) in infants and children and investigation of its causes remains perplexing in clinical practice.
The Hepatology Committee of ESPGHAN has decided to organize a three-day Monothematic Conference in order to share the latest expertise on the diagnosis and management of ALF in the pediatric age group.
Specifically, the epidemiology, the clinical presentation of ALF and its causes in all pediatric age groups will be discussed providing clinical tips for suspicion of underlying metabolic liver disease. The role of liver biopsy and molecular testing will be discussed, as well as the criteria for transfer to a tertiary care center. Management of complications such as hepatic encephalopathy, coagulopathy, ascites and renal disease will be discussed in one session. Another session, will concentrate on nutrition support, the role of artificial liver/kidney support devices and the indications of liver transplantation in each setting.
Future research goals, and present clinical dilemmas in the diagnosis and management of ALF, will be discussed, by a panel of experienced hepatologists.
We expect to attract gastroenterologists and hepatologists for pediatric and for adult patients, pediatric and hepatobiliary surgeons, from Europe and around the world and to encourage collaboration and exchange of knowledge.
REGISTRATION (to open September 01 2019)
Registration Deadline: November 30, 2019
Early Bird: November 15, 2019
Late Registration: November 30, 2019
Please use the online regsistration on this page to regsiter for the conference. regsitrations by email cannot be accepted. Should you experience any issues with the registration tool, please contact firstname.lastname@example.org.
Participants will be selected on a first come first serve basis. The number of participants is limited. Kindly be aware that the conference might thus be full before the deadline. Additional registrants will be added to our waiting list. Priority will be given to ESPGHAN Members.
Aglaia Zellos (Local Organiser)
Henkjan Verkade (Chair ESPGHAN Hepatology Committee)
General rules for abstract submission: to be confirmed
Deadline for submission: 1 December 2019
Thursday, January 30
Session 1. Acute liver failure-Diagnosis
14.00-14.30 Definition of ALF and Epidemiology–where do we stand?
14.30-15.00 Clinical presentation and lab findings
15.00-15.30 Causes of ALF in infants and children
15.30-16.00 Coffee Break
16.00-16.30 Is metabolic liver disease involved? Clinical tips for diagnosis
16.30-17.00 Initial diagnostic approach-role of DNA testing, bone marrow biopsy
17.00-17.30 Liver biopsy: is it necessary?
17.30-18.15 When to refer to a tertiary center?
Friday, January 31
Session 2. Acute liver Failure-Initial Management
09.00 – 09.30 Management of DILI and toxins
09.45-10.15 Management of metabolic liver disease
10.15-10.45 Management of bacterial and viral infections
10.45-11.15 Complications of ALF
11.45-11.15 Hepatic encephalopathy
11.15-11:45 Coagulopathy and Renal disease
12.00- 12:30 Keynote Lecture
Session 3. Acute liver Failure-Treatment
14.00-14.30 Nutrition support
14.45-15.15 What is the role of artificial liver/kidney support devices?
15.15-15.45 Liver transplantation: indications and criteria
15.45-16.15 Liver transplantation: options and contraindications
16.30-17.00 Liver transplantation: prognostic models and predictors of outcome
17.00-17.30 Summary of Recommendations on medical management
Saturday January 01
Session 4. ALF: Dilemmas and Future Research
09.00 – 09.15 Abstract
09.15 – 09.45 Challenges in the diagnosis of ALF
09.45 – 10.15 Dilemmas in the management of ALF
10.15 – 10.45 Ancillary support
10.45 – 11.15 Coffee Break
11.15 – 11.45 Future directions of research
11.45 – 12.15 Summary and closing remarks