Monothematic Conference: Acute Liver Failure

General Information 

Knowledge in the diagnostic and therapeutic management of several liver diseases of has increased in the past decades. However, management of acute liver failure (ALF) in infants and children and investigation of its causes remains perplexing in clinical practice.

The Hepatology Committee of ESPGHAN has decided to organize a three-day Monothematic Conference in order to share the latest expertise on the diagnosis and management of ALF in the pediatric age group.

Specifically, the epidemiology, the clinical presentation of ALF and its causes in all pediatric age groups will be discussed providing clinical tips for suspicion of underlying metabolic liver disease. The role of liver biopsy and molecular testing will be discussed, as well as the criteria for transfer to a tertiary care center. Management of complications such as hepatic encephalopathy, coagulopathy, ascites and renal disease will be discussed in one session. Another session, will concentrate on nutrition support, the role of artificial liver/kidney support devices and the indications of liver transplantation in each setting.

Future research goals, and present clinical dilemmas in the diagnosis and management of ALF, will be discussed, by a panel of experienced hepatologists.

We expect to attract gastroenterologists and hepatologists for pediatric and for adult patients, pediatric and hepatobiliary surgeons, from Europe and around the world and to encourage collaboration and exchange of knowledge.

REGISTRATION (to open September 01 2019)

Registration Deadline: November 30, 2019

Early Bird: November 15, 2019

Late Registration: November 30, 2019

Please use the online regsistration on this page to regsiter for the conference. regsitrations by email cannot be accepted. Should you experience any issues with the registration tool, please contact

Participants will be selected on a first come first serve basis. The number of participants is limited. Kindly be aware that the conference might thus be full before the deadline. Additional registrants will be added to our waiting list. Priority will be given to ESPGHAN Members.


Aglaia Zellos (Local Organiser)

Henkjan Verkade (Chair ESPGHAN Hepatology Committee)

Dominique Debray

Yael Mozer-Glassberg

Piotr Czubkowski

Valerie McLin

General rules for abstract submission: to be confirmed

Deadline for submission: 1 December 2019

Preliminary Program

Thursday, January 30 

Session 1. Acute liver failure-Diagnosis

14.00-14.30 Definition of ALF and Epidemiology–where do we stand?

14.30-15.00 Clinical presentation and lab findings

15.00-15.30 Causes of ALF in infants and children

15.30-16.00 Coffee Break

16.00-16.30 Is metabolic liver disease involved? Clinical tips for diagnosis

16.30-17.00 Initial diagnostic approach-role of DNA testing, bone marrow biopsy  

17.00-17.30 Liver biopsy: is it necessary?

17.30-18.15 When to refer to a tertiary center?

Friday, January 31 

Session 2. Acute liver Failure-Initial Management

09.00 – 09.30 Management of DILI and toxins

09.30-09.45 Abstract

09.45-10.15 Management of metabolic liver disease

10.15-10.45 Management of bacterial and viral infections

10.45-11.15 Complications of ALF 

11.45-11.15 Hepatic encephalopathy

11.15-11:45 Coagulopathy and Renal disease

11.45-12.00 Abstract

12.00- 12:30 Keynote Lecture

12.30-14.00 Lunch

Session 3. Acute liver Failure-Treatment

14.00-14.30 Nutrition support

14.30-14.45 Abstract

14.45-15.15 What is the role of artificial liver/kidney support devices?

15.15-15.45 Liver transplantation: indications and criteria

15.45-16.15 Liver transplantation: options and contraindications  

16.15-16.30 Abstract

16.30-17.00 Liver transplantation: prognostic models and predictors of outcome

17.00-17.30 Summary of Recommendations on medical management

Saturday January 01 

Session 4. ALF: Dilemmas and Future Research

09.00 – 09.15 Abstract

09.15 – 09.45 Challenges in the diagnosis of ALF

09.45 – 10.15 Dilemmas in the management of ALF

10.15 – 10.45 Ancillary support 

10.45 – 11.15 Coffee Break

11.15 – 11.45 Future directions of research

11.45 – 12.15 Summary and closing remarks

Coming soon.