Monothematic Meeting

Monothematic Conference on Cystic Fibrosis related Liver disease

January 28th-29th, 2016

Imagine Institute, Paris, France

Organising committee 

  • Dominique DEBRAY, MD, PhD; Heptatology Committee member and secretary of the ESPGHAN, CF and Pancreatic Disease Working Group
  • Henkjan J. VERKADE, MD, PhD; Heptatology Committee member
  • Thierry LAMIREAU, MD, PhD; Heptatology Committee member
  • Michael WILSCHANSKI, MBBS ;  Chair ESPGHAN, CF and Pancreatic Disease Working Group

Rationale

Cystic fibrosis (CF) is the most frequent autosomal recessive disorder in Caucasians. With the improvement in the management of lung disease and nutrition and the increased life expectancy of CF patients, CF-related liver disease (CFLD) has become clinically more important and one of the leading causes of death among patients with CF. The detailed pathophysiology and prognostic factors for the long-term evolution of CFLD have remained unclear.

Three developments are expected to have major influences on the prevention and treatment of CFLD and on the understanding of its pathophysiology.

  1. the increased life expectancy of CF patients has led to CFLD patients advancing well into adult life. The clinical course of CFLD in adult CF patients, however, has not been characterized, nor the prognostic factors for long-term complications;
  2. the emergence of novel treatments, either CF specific (correctors or potentiators) or aspecific (bile acid analogues, antifibrotic agents), necessitate the identification of defined criteria of (stages of) CFLD and of biomarkers for the severity of CFLD disease;
  3. the availability of novel experimental models allow for more detailed pathophysiologic and mechanistic studies to identify the underlying mechanisms of CFLD and possible targets of interventions. Recently the possible roles of the intestinal microbiome, of nuclear hormone activation and of extra-epithelial expression of CFTR in the development of CFLD have been hypothesized. 

Objective of this meeting

The goal of the meeting is to provide an overview of these three emerging fields with respect to CFLD:

  • the clinical course of CFLD into adulthood;
  • the definition of relevant parameters for CFLD development and severity to assess the effects of novel treatments;
  • the understanding of CFLD development based on studies in novel experimental models

Registration

For more information and registration please visit: www.espghan-cfld2016.paris


Past meetings:

2014 

Single topic symposium on Metabolic Liver Disease,

October 2-4, 2014, Birmingham, UK

This meeting was organised on behalf of the ESPGHAN Hepatology Committee with support from UEG, EASL and the BIMDG.  The programme featured international speakers who discussed established and novel medical treatments, stem cell and liver transplants, how to use clinical and histopathology to diagnose metabolic liver diseases and many more topics. We also invited participants to bring along difficult cases for discussion. This meeting provided both a statement of current expertise and discussions on future prospects in this field

Website: www.metabolicliverdisease2014.org

Single topic symposium on Metabolic Liver Disease Programme

2013

Current paradigms and novel strategies in paediatric liver transplantation
September 12-14, 2013, Hannover, Germany

Over the last 25 years paediatric liver transplantation has emerged from an experimental concept to an established medical therapy. This successful development forces us to continuously consider new approaches to further improve the care of liver transplanted children.

This monothematic conference on paediatric liver transplantation is organized on behalf of the ESPGHAN Hepatology Committee. The focus will be on improving late outcomes and organ allocation strategies, transplant immunology and new and challenging indications. Single centre experiences, pro- and con debates, as well as deeper reviews will be presented with the primary objective to encourage constructive discussions. We aim to provide both a statement of current expertise and discussions on future prospects in our field!

Current paradigms and novel strategies in paediatric liver transplantation brochure