Date: November 30, 2023. 17:00 – 18:00 CET
Registration deadline: November 29, 2023
Renata Auricchio, MD, PhD
Associate Professor in Pediatrics
Department of Translation Medical Science, Pediatric Section
European Laboratory for the Investigation of Food Induced Disease (ELFID)
University Federico II, Naples
Ilma Korponay-Szabo M.D., Ph.D.
Department of Pediatrics, Faculty of Medicine, University of Debrecen & Celiac Disease Center, Heim Pál National Paediatric Institute, 1089 Budapest, Hungary
ESPGHAN Guidelines for Diagnosing Coeliac Disease of 2012 and 2020 establish the possibility of the non-biopsy approach for CD diagnosis in children with symptoms suggestive of CD but also eventually in asymptomatic children, with serum levels of_10 times the upper limit of normal of TGA-IgA and positive EMA-IgA in a second serum sample. Thus reliable testing is crucial to avoid under and over diagnosis and in this respect guidelines recommend to use only antibody tests with proper calibrator curve-based calculation, and having the 10 x ULN value within their measurement range. Reports on TTG should specify the test used and the cut off levels.
EMA results should contain the specification of the investigated immunoglobulin class, the cutoff dilution, interpretation (positive or negative), the highest dilution still positive and the specification of the substrate tissue. Also, laboratories providing CD-specific antibody test results for diagnostic use should continuously participate in quality control programmes at a national or an international level. Efficiency of the test together with challenging aspects of test interpretation will be addressed during this webinar by relevant experts in the field.