Monothematic on Cystic Fibrosis and Hepato-bilio-pancreatic Diseases in Children

April 15 - 16, 2027
Woluwé Saint Lambert (Brussels), Belgium

General Information

Cystic Fibrosis is a multivisceral disease, that involves lung, gut, and liver, as well as other systems. Since 2012, several CFTR-modulating therapies have been developed targeting the underlying molecular defect. The real-life impact of these drugs is becoming CF into a chronic disease, and its impact on different organs is until now, unknown.

These therapies are transforming CF into a chronic condition; however, their long-term impact on extrapulmonary organs remains incompletely understood.

Cystic fibrosis–related liver disease (CFLD) must be carefully distinguished from other hepatic manifestations that may lack clinical significance. Both the clinical presentation and histological severity of CFLD are highly variable among patients.

This conference provides an opportunity to deepen our understanding of CFLD pathogenesis, current diagnostic and management strategies, and to evaluate the emerging evidence on how CFTR modulators may influence hepatobiliary outcomes in CF.

The course language is English.

Registration & Fees

Registration Deadline: February 15, 2027
Registration Fees:
ESPGHAN Member Regular: EUR 250.00
ESPGHAN Trainee Member (YE): EUR 150.00
Non-Member General: EUR 300.00
Non-Member Trainee: EUR 250.00
 

Kindly use the online application form on this page. Applications submitted by email cannot be accepted. If you experience any issues with the tool, please contact us at office@espghan. Candidates will be selected based on an abstract that may be selected for presentation during the course. Abstracts may have been submitted to other public meetings previously. If you do not have a suitable abstract a motivation letter is required instead.

Please do not make travel arrangements before receipt of a formal confirmation of acceptance from the ESPGHAN Office. The number of participants is limited and a selection will be made by ESPGHAN after the deadline. Priority will be given to ESPGHAN Members.
ESPGHAN Members may attend two courses per year while non-members may attend one course before becoming members of the society. 

Delegates are expected to attend the full course and arrange their travel according to the course schedule. 

Abstract Submission Guidelines:
Language : English
Abstract word count : maximum 400
Title length: inclusive in total word count
Tables : maximum 2
Figure maximum 1
Details of authors: presenters name to be included and underlined
Number of coauthors : no restriction
Who can present : no restriction; any of the co-authors can present but should be registered for the school and have paid the registration fee. Presenters should have a medical / allied health professional background.
What can be submitted: preferrably complex / unresolved case reports or original work
Trial design abstract may be considered at the discretion of the abstract selection committee
Presentation: oral; Authors will be notified about selection.

PRELIMINARY PROGRAMME

Programme

Day 01 - April 15

12:00–12:40 Delegate Arrival & Walking Lunch

12:40–12:50 Welcome and Introduction

LIVER DISEASE IN CF – Epidemiology and Clinical Assessment

12:50–13:10 Epidemiology of Cystic Fibrosis in Europe 

13:10–13:30 Definition and Spectrum of CFHBIF. 

13:30–13:50 Biomarkers and Assessment of CFHBI 

13:50–14:10 Screening and Surveillance Strategies for CFHBI 

Pathophysiology of Liver Disease in CF

14:10–14:30 Porto-Sinusoidal Vascular Disease in Cystic Fibrosis

14:30–14:50 Does the Gut–Liver Axis Impact CFHBI? 

14:50–15:20 Difficult Clinical Cases & Abstract Discussion

15:20–15:50 Coffee Break

CFHBI in the Era of Modulators

15:50–16:10 CFTR Modulators: Mechanisms, Classes and Genotype Eligibility

16:10–16:30 Side Effects and Contraindications of Modulators

16:30–16:50 The Changing Clinical Picture of CF Since Modulators

16:50–17:20 CFHBI in the Era of Modulators – What Do We Know in Children and

Young Adults? 

17:20–17:40 Is There Still a Role for Organ Transplantation in CF?

18:00 Social Activity & Dinner

Day 02 - April 16

PANCREAS AND NUTRITION IN CF – Disease Spectrum and Impact of Modulators

09:00–09:20 The CFTR protein in the pancreas and pathophysiology of CFTR

mutation in the developing pancreas 

09:20–09:40 Epidemiology of EPI and Pancreatitis in CF 

09:40–10:00 Impact of Modulators on Pancreatic Function 

10:00–10:20 Role of Modulators in CFTR-Related Disorders 

10:20–10:50 Difficult Clinical Cases & Abstract Discussion

10:50–11:10 Coffee Break

Nutrition, EPI and PERT

11:10–11:30 Role of the Dietitian in the Era of Modulators

11:30–11:50 Diagnosis and Monitoring of Exocrine Pancreatic Insufficiency

11:50–12:10 PERT De-escalation in the Era of Modulators C. Smith (UK)/

12:10–12:30 Management of Overweight and Obesity in CF

12:30–13:30 Walking Lunch

Changing Paradigms in CF Care

13:30–13:50 Psychosocial Impact of Modulators

13:50–14:10 Quality of Life in the Modulator Era 

14:10–14:30 Aging with Cystic Fibrosis 

Future Directions & Precision Medicine in CF

14:30–14:50 Is There a Place for Modulators to treat the fetus? 

14:50–15:10 Organoids and Precision Medicine in CFTR related diseases 

15:10–15:30 Difficult Clinical Cases & Abstract Discussion

15:30–16:10 Future Challenges and Emerging Therapies – Panel Discussion

Faculty

16:10–16:20 Closing Remarks

Cost Coverage

ESPGHAN will cover the following for onsite delegates

  • Accommodation on April 15 (arranged by ESPGHAN)
  • Dinner on April 15
  • Course catering 
  • Course Material if applicable

 

CONTACT

If you have any questions, please contact the ESPGHAN Office for details.
Phone: +41 (0)22 9000 401
Email: office@espghan.org